Alireza Yazdani

Academic Background

I received my PhD degree in Mechanical and Aerospace Engineering from Rutgers University in 2012. My PhD studies and dissertation were directed at the complex dynamics and behavior of soft biological cells such as erythrocytes red blood cells), capsules and vesicles in the flow. Healthy erythrocyte membranes possess unique viscoelastic properties that make them extremely deformable.

I studied the intricate dynamics of microsocpic deformable cells in shear flow using the continuum-based Immersed-boundary Front-tracking method. The behavior of single red cells in dilute suspensions may explain the overall behavior and rheology of blood as a dense suspension of high erythrocyte concentration. Altogether, the flow of healthy and disease erythrocytes in blood especially in small vessels has been under extensive investigation due to its physiologic and biophysical significance.

Education

  • Ph.D., Mechanical and Aerospace Engineering, Rutgers University, NJ-USA (2012)
  • M.Sc., Mechanical Engineering – Thermal and Fluid Sciences, Iran University of Science and Technology, Tehran-Iran (2007)
  • B.Sc., Mechanical Engineering – Thermal and Fluid Sciences, K.N Toosi University of Technology, Tehran-Iran (2004)

Research Interests and Activities

I joined Division of Applied Mathematics and the CRUNCH Group at Brown University in 2013 as a post-doctoral research associate. My research interests at Brown is broad and mostly focused on the multiscale, multiphysics nature of biological processes. I am mainly studying blood coagulation and thrombus biochemomechanics in the vasculature especially in aneurysms and aortic dissections.

In computational biophysics, we often use modeling and simulations techniques in one of the spatial and temporal scales: (1) Microscale with techniques such as Molecular Dynamics, (2) Macroscale with techniques such as Continuum Theory and Finite Element Methods, and (3) intermediate Mesoscales with techniques such as Dissipative Particle Dynamics (DPD). These methods at each scale have their advantages and limitations, and multiscale modeling employing techniques across two or more spatial and temporal levels is desirable, indeed, necessary for understanding many phenomena that are intrinsically multiscale.

Blood coagulation is a multiscale process, and hence, numerical models utilize the mesoscale DPD simulations to address the associated formation of thrombus, i.e., platelet activation and aggregation, including interactions with red blood cells plus the accumulation of fibrin polymers as well as the continuum-level modeling of unsteady blood flow interactions with the thrombosed region.

Areas of Expertise

  • Computational Fluid Dynamics and Finite/Spectral Element Analysis
  • Mesoscopic Modeling of Simple and Complex Fluids
  • Fluid-structure Interaction and Immersed Boundary Method
  • Computational Bio- and Micro-Fluid Mechanics

Publications and Presentations

Journal Publications

  1. Daniel Cordasco, Alireza Yazdani, and Prosenjit Bagchi, “Comparison of erythrocyte dynamics in shear flow under different stress-free configurations.” Physics of Fluids (2014)DOI: 10.1063/1.4871300.
  2. Alireza Yazdani and Prosenjit Bagchi, “Influence of membrane viscosity on capsule dynamics in shear flow.” Journal of Fluid Mechanics (2013) DOI: 10.1017/jfm.2012.637.
  3. Prosenjit Bagchi and Alireza Z.K. Yazdani, “Analysis of membrane tank-tread of nonspherical capsules and red blood cells.” European Physical Journal E (2012) DOI: 10.1140/epje/i2012-12103-1.
  4. Alireza Yazdani and Prosenjit Bagchi, “Three-dimensional numerical simulation of vesicle dynamics using front-tracking method.” Physical Review E (2012) DOI: 10.1103/PhysRevE.85.056308.
  5. Alireza Z.K. Yazdani and Prosenjit Bagchi, “Phase diagram and breathing dynamics of a single red blood cell and a biconcave capsule in dilute shear flow.” Physical Review E (2011) DOI: 10.1103/PhysRevE.84.026314.
  6. Alireza Z.K. Yazdani, R. Murthy Kalluri, and Prosenjit Bagchi, “Tank-treading and tumbling frequencies of capsules and red blood cells.” Physical Review E (2011) DOI: 10.1103/PhysRevE.83.046305.

Conference Publications and Talks

  1. “Mesoscopic Modeling of Thrombus Formation and Growth: Platelet Deposition in Complex Geometries.” 67th Annual Meeting of the APS Division of Fluid Dynamics, San Francisco, California, Nov. 2014.
  2. “Multi-scale Modeling of Thrombus Formation and Growth in Aortic Dissection.” 7th World Congress of Biomechanics, Boston, Massachusetts, Jul. 2014.
  3. “Computational Fluid Dynamics Modeling of Effective Upper Airway Compliance in Subjects with Polycystic Ovarian Syndrome and Obstructive Sleep Apnea.” American Thoracic Society International Conference, Philadelphia, Pennsylvania, May 2013, Poster Presentation.
  4. “Influence of Membrane Viscosity on Dynamics of Capsules and Red Blood Cells.” 65th Annual Meeting of the APS Division of Fluid Dynamics, San Diego, California, Nov. 2012.
  5. “Numerical Analysis of Vesicle Dynamics in Linear Shear Flow.” 64th Annual Meeting of the APS Division of Fluid Dynamics, Baltimore, Maryland, Nov. 2011.
  6. S.M. Hosseinalipour, A. Zarif Khalili, A. Salimi, “Numerical simulation of pig motion through gas pipelines”. 16th Australasian Fluid Mechanics Conference (AFMC), 971-975, Dec. 2007.

Affiliations

Member of

  • American Physical Society (APS)
  • American Society of Mechanical Engineers (ASME)

Reviewer of

  • Journal of Computational Physics
  • Physical Review E
  • Journal of the Royal Society: Interface
  • Journal of Biomechanics
  • Computer Methods in Applied Mechanics and Engineering
  • Drug Discovery Today

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