Scientific Computing Group Seminars - Detail View

Speaker: Ching-Shan Chou

Affiliation: University of California at Irvine

Talk Title: Spatial dynamics of cell signaling

Invited by: Chi-Wang Shu

Time: Jan. 09 2009 11 a.m.

Location: 182 George Street, Room 110

Abstract:

Spatial heterogeneity of molecules or cells is functionally important to biological systems, and it is often achieved or induced by cell signaling. One of the central questions in cell and developmental biology is to identify and understand the underlying mechanisms of the emergence, the robustness and the dynamics of the spatial patterning. In this talk, I will present our study on two biological systems: (1) cell polarization in yeast pheromone sensing, (2) multi-stage cell lineage in epithelium, in which we investigated the strategic control of the systems through modeling with partial differential equations and computational analysis. In addition to modeling, I will also discuss computational challenges that arise from exploring such biological models.