APMA 0410
Mathematical Methods in the Brain Sciences

Fall 2012

 

Last updated December 22, 2012

 

Grades

 

Recommended reading:

Dynamical Systems in Neuroscience – The Geometry of Excitability and Bursting

By Eugene Izhikevich

e-book  (available to Brown users)

 

 

 

HOMEWORKS

Please hand in paper copy in class on due date

Matlab assignments: include printout of code as well as figures

 

 

Homework 1 - Due Wednesday September 19       Solutions

Homework 2 - Due Monday October 1                 Solutions

Homework 3 - Due Wednesday October 10          Solutions

Homework 4 - Due Friday November 2                Solutions     hw4.m

Homework 5 - Due Monday November 19           Solutions

Homework 6 - Due Wednesday December 5         Solutions

 


 

FINAL EXAM

Thursday 12/20/2012  2:00 PM

Barus and Holley 160

 

Exam

 

Solutions

 

 

Coverage: all material studied sinde midterm.

No computers or calculators of any kind allowed.

 

Practice Exam                Solutions

 

 

 

 

Review Session – Wed Dec 12, 2012

 

 

Class 37 – Fri Dec 7, 2012

 

 

The Lotka-Volterra Predator-Prey Model

The Lorenz system and its strange attractor   code

 

 

 

Class 36 – Wed Dec 5, 2012

 

 

The Poincare-Bendixson Theorem

The Saddle-Node Bifurcation

An Excitatory-Inhibitory Neural-Network Model

 

 

 

Class 35 – Mon Dec 3, 2012

 

 

The Hopf Bifurcation

The FitzHugh-Nagumo Model      fitzhugh_nagumo.m

 

 

 

Class 34 – Fri Nov 30, 2012

 

 

Linearization of Non-Linear Systems (continued)

 

 

 

Class 33 – Wed Nov 28, 2012

 

 

Linearization of Non-Linear Systems

 

 

 

Class 32 – Mon Nov 26, 2012

 

 

Systems of Non-Linear DEs: Examples (continued)

Code: First_Order_System.m

 

 

 

Class 31 – Mon Nov 19, 2012

 

An example of Eigenvector Analysis in Brain Science:

      The Brain-State-in-a-Box (BSB) Model

                     (James Anderson et al. 1977)

      Applications of the BSB Model

 

Systems of Non-Linear DEs: Examples

 

 

 

Class 30 – Fri Nov 16, 2012

 

 

Four-Step Study of Systems of Linear DEs

Four-Step-Study Examples

IVP Example

 

 

 

Class 29 – Wed Nov 14, 2012

 

 

Systems of Linear DEs: Eigenvector Analysis (continued)

 

 

 

Class 28 – Mon Nov 12, 2012

 

 

Systems of Linear DEs: Eigenvector Analysis

 

 

 

Class 27 – Fri Nov 9, 2012

 

 

Systems of Linear DEs: Examples (continued)

Code: Linear_First_Order_System.m

 

 

 

Class 26 – Wed Nov 7, 2012

 

 

Systems of Linear DEs: Examples

 

 

 

Class 25 – Mon Nov 5, 2012

 

 

More examples (continued)

 

 

 

Class 24 – Fri Nov 2, 2012

 

 

Non-Homogeneous Linear Differential Equations (continued)

 

More examples (continued)

 

 

 

Class 23 – Wed Oct 31, 2012

 

 

Non-Homogeneous Linear Differential Equations

 

More examples

 

 

 

Class 22 – Fri Oct 26, 2012

 

 

Linear first-order DE (code)

   Simple code – can be used as template for HWs

 

First-order DEs with direction field (code)

    More complicated code, with various functionalities

 

Two interesting examples

 

 

 

Class 21 – Wed Oct 24, 2012

 

 

Qualitative Analysis of Differential Equations (continued)

 

Separable Differential Equations

 

 

 

Class 20 – Mon Oct 22, 2012

 

 

Introduction to Differential Equations (continued)

Nice Tutorial on Membrane Equation

    (courtesy of David Heeger)

Qualitative Analysis of Differential Equations

 

 

 

Class 19 – Fri Oct 19, 2012

 

 

Introduction to Differential Equations (continued)

Bacteria Growth (code)

 

 

 

Class 18 – Wed Oct 17, 2012

 

 

Introduction to Differential Equations

 

 

 

Class 17 – Mon Oct 15, 2012

 

 

Mock f-MRI

fmri_decoding.m

fmri_dataset_1.mat

ROC_construction.m

compute_score.m

fmri_simulation.m

 

 

 

MIDTERM EXAM – Sun Oct 14, 2012

Barus and Holley 141

 

Solutions

 

 

Coverage: all material studied until exam.

No computers or calculators of any kind allowed.

You will not be asked to compute numerical values of complicated expressions or expressions that involve exponentials or similar functions.

Practice Midterm Exam       Solutions

 

 

 

Class 16 – Fri Oct 12, 2012

 

 

Approximations      Approximations (code)

 

Hypothesis Testing I

 

Hypothesis Testing II

 

 

 

Class 15 – Wed Oct 10, 2012

 

 

Continuous RVs

 

Review of properties of RVs

 

The Poisson Neuron, the Exponential distribution, and the Poisson distribution (continued)

 

 

 

Class 14 – Fri Oct 5, 2012

 

 

The Poisson Neuron, the Exponential distribution, and the Poisson distribution

 

 

 

Class 13 – Wed Oct 3, 2012

 

 

Poisson_neuron.m

 

 

 

Class 12 – Mon Oct 1, 2012

 

Covariances and related notions

 

 

 

Class 11 – Fri Sept 28, 2012

 

Basic Statistics for the Binomial Distribution

The case of the forgetful professor

 

 

 

Class 10 – Wed Sept 26, 2012

taught by Dahlia Nadkarni

 

Independent RVs, Means, Variances (continued)

Geometric distribution

 

 

 

Class 9 – Mon Sept 24, 2012

 

Independent RVs, Means, Variances

 

 

 

Class 8 – Fri Sept 21, 2012

 

Binomial Distribution (continued)

binomial_distr.m

birthdays.m (Matlab Example)

 

 

 

Class 7 – Wed Sept 19, 2012

taught by Dahlia Nadkarni

 

Binomial Distribution

 

 

 

Class 6 – Mon Sept 17, 2012

 

 

Bayesian Inference

Random Variables

  

 

 

Class 5 – Fri Sept 14, 2012

 

 

Conditional Probabilities

  

 

 

Class 4 – Wed Sept 12, 2012

 

 

Example of Probability on Infinite Discrete Sample Space

  

 

 

Class 3 – Mon Sept 10, 2012

 

 

 Sample Spaces

 

 Events

 

 Probabilities

  

 

 

Class 2 – Fri Sept 7, 2012

 

Matlab Examples

 

1.   Food-Passing Game

2.   Probability

                            Coins_and_Neurons.m

3.       Differential equations

3.1 Linear_System.m

3.2 The Hodgkin-Huxley model

o      Sir Andrew Huxley

o      Hodgkin-Huxley model

o      Hodgkin_Huxley_model.m

  

 

 

Class 1 – Wed Sept 5, 2012

o        Organizational matters (see Information Sheet).

o        Asking whether a neuron fired in a given millisecond is a random experiment.

o        Flipping a coin (whether fair or biased) is also a random experiment.

o        Neuron firing and coin flipping involve two very different types of randomness. Yet both are captured adequately in a single mathematical framework.

o        General remarks on applied math, probability and differential equations: conciseness, generality, explanatory power, predictive power.

 

Information Sheet (includes syllabus)    

 

Lecture

MWF 2:00-2:50, J. Walter Wilson 301

 

Instructor

            Elie Bienenstock          email: firstname [at] brown [period] dam [period] edu

                  Office Hours: please email me to set appointment

 

Computer TA

       

Grader